Oxytocin — Evidence
Clinical trials and publications sourced from ClinicalTrials.gov, PubMed, and FDA. Updated hourly by the automated crawler.
Registered studies (50)
From the ClinicalTrials.gov record captured for this substance. Registration is not evidence of approval, efficacy, or safety.
Acute Effects of Intravenous 5-MeO-DMT in Healthy Participants
Harm Reduction Intervention for Anabolic-androgenic Steroids Users: a Randomized Controlled Trial
Anticholinergics for Cervical Edema in Labor
Tolerability of MDMA in Schizophrenia
Castor Oil Ingestion and Balloon Catheter for Labor Induction in Nulliparous
High Or Low Dose pOstpartUm Oxytocin at the Time of Cesarean Birth
Low-Dose Versus High-Dose Oxytocin Dosing for Induction and Augmentation of Labor
Efficacy of Carbetocin Versus Oxytocin Plus Misoprostol in Decreasing Blood Loss During Cesarean Section
Effect of Intranasal Oxytocin on Dysphagia in Children and Adolescents With Prader-Willi Syndrome
Effects of Glucagon-like-Peptide-1 Analogues on Sexuality
Brain Changes in Response to Long-Duration Isolation and Confinement
Community Singing Interventions for Postnatal Depression: a Hybrid Type II Effectiveness-implementation Trial
Spinal Fentanyl or Epidural Analgesia in the Early First Phase of Induced Labor
Amniotomy for Second-trimester Pregnancy Termination
Oral Oxytocin's Effects on Attention Control
Video Debriefing at the Delivery Ward
Pre-operative Intranasal Oxytocin for Enhancing Bariatric-induced Diabetes Remission
Cervical Traction vs. Active Management of 3rd Stage of Labor
Carbetocin Versus Oxytocin Infusion Plus Tranexamic Acid During Cesarean Section
Risk Factors for Postpartum Hemorrhage
Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section
A Trial of TTA-121 on Autism Spectrum Disorder
Nefopam vs Tramadol in the Prevention of Post Anaesthetic Shivering
Oxytocin Effects on the Prosocial Learning
Prevention of Postpartum Hemorrhage With TXA
Effects of Oxytocin on Negative Symptoms and Social Cognition in Schizophrenia and Its Possible Mechanisms
Differential Effects of Vasopressin and Oxytocin on Attention Control
Studies of Mothers With Postnatal Depression
Oxytocin and Brain Responses in Maternal Addiction
Oxytocin in Alcohol Use Disorder
Induction of Labor in Women With Unfavorable Cervix: Dilapan Versus Foley Bulb
Hexakaprone Treatment for Post-Partum Hemorrhage Prophylactic
Oxytocin on HR in Sleep Apnea Patient
Effects of Beer (Alcohol) on Social Cognition
Foley With Oxytocin Versus Foley no Oxytocin for Induction of Labor
Oxytocin Suppresses Substance Use Disorders Associated With Chronic Stress
Postpartum Uterotonic Administration
High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour
Fetal Copeptin After Oxytocin Challenge Test
Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section
IV vs IM Oxytocin in the Third Stage of Labor for Prevention of Postpartum Hemorrhage
Misoprostol for Secondary Prevention of Postpartum Hemorrhage at the Community Level in India
A Comparison of Transcervical Foley Catheter and Prostaglandins for Induction of Labor at Term
Antipsychotic Effects of Oxytocin
SEGATROM: Sensory and Gastrointestinal Impact of Taste Receptor Variants on Human Metabolism and Nutrition
Brain Blood Flow Changes Elicited by Oxytocin in Volunteers With and Without Schizophrenia
Oxytocin and Social Behavior Over the Lifespan
Buccal Misoprostol During Cesarean Section for Preventing Postpartum Hemorrhage
Effect of Oxytocin and Vasopressin Antagonists on Uterine Contractions
ClinicalTrials.gov (13)
Oxytocin to Enhance Integrated Treatment for AUD and PTSD
Phase PHASE2 · COMPLETED · Sponsor: Medical University of South Carolina
Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening
Phase PHASE3 · RECRUITING · Sponsor: University Hospital, Tours
Mind-Body Group Interventions for Psychological Distress in Young Breast Cancer Survivors
Phase NA · NOT_YET_RECRUITING · Sponsor: University of Alabama at Birmingham
Evaluation of Comprehensive Emergency Obstetric and Neonatal Care Program in Malawi
Phase N/A · NOT_YET_RECRUITING · Sponsor: CDC Foundation
Different Medications to Induce Labor
Phase PHASE3 · RECRUITING · Sponsor: Icahn School of Medicine at Mount Sinai
Auricular Transcutaneous Electrical Nerve Stimulation Treatment of Autism
Phase NA · RECRUITING · Sponsor: Massachusetts General Hospital
Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency
Phase PHASE1 · RECRUITING · Sponsor: Elizabeth Austen Lawson
Inducing Self-Dehumanization to Examine Oxytocin and Suicide Risk
Phase NA · NOT_YET_RECRUITING · Sponsor: Florida State University
Patient Empowerment and Agency Through Intrapartum Counseling and Education
Phase NA · COMPLETED · Sponsor: Oregon Health and Science University
Open, Randomized Feasibility Trial on the Safety and Performance of the INGA Catheter for Labor Induction
Phase NA · RECRUITING · Sponsor: Aalto University
Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease
Phase EARLY_PHASE1 · RECRUITING · Sponsor: Massachusetts General Hospital
Ripening Approaches for Prompt Induction and Delivery - Sequential Versus Concurrent Dilapan-S and Misoprostol to Achieve Vaginal Delivery (RAPID-DS)
Phase NA · NOT_YET_RECRUITING · Sponsor: Ochsner Health System
The Efficacy of Carbitocin in Reduction of Blood Loss During Myomectomy
Phase EARLY_PHASE1 · NOT_YET_RECRUITING · Sponsor: Alex Ekwueme Federal University Teaching Hospital
PubMed (28)
Oral Misoprostol Versus Vaginal Dinoprostone for Labor Induction: A Systematic Review and Meta-Analysis.
The journal of obstetrics and gynaecology research · 2026 Aug · DOI: 10.1111/jog.70369
Progesterone regulates the secretion of GnRH in bovine endometrial cells via the Erk1/2-ARRB1 pathway.
Theriogenology · 2026 Jul 16 · DOI: 10.1016/j.theriogenology.2026.118079
Maturation of social adaptation circuits from ontogeny to pathology.
Neuroscience and biobehavioral reviews · 2026 Jul 17 · DOI: 10.1016/j.neubiorev.2026.106874
Comparative efficacy of pharmacological, adjunctive, and non-pharmacological interventions across behavioral domains in children and adolescents with autism spectrum disorder: a network meta-analysis.
Child and adolescent psychiatry and mental health · 2026 Jul 17 · DOI: 10.1186/s13034-026-01132-2
Late-pregnancy oxytocin alleviates neuroinflammation and hyperalgesia in chronic migraine model via PVN to NTS oxytocinergic projections and ECM-receptor interaction signaling.
Brain, behavior, and immunity · 2026 Jul 19 · DOI: 10.1016/j.bbi.2026.106919
The Effects of Oxytocin on Stressed Rats with Increased Urinary Frequency.
International neurourology journal · 2026 Jul 17 · DOI: 10.5213/inj.2550358.179
Plasticity of subfornical organ astrocyte structure and supraoptic nucleus hormone expression following extreme dehydration in the desert rodent Gerbillus tarabuli.
Journal of neuroendocrinology · 2026 Jul · DOI: 10.1111/jne.70236
Intranasal Vasopressin Decreases Voluntary Ethanol Drinking in Single- and Group-Housed Mice Through Mechanisms Involving Vasopressin 1a and 1b Receptors.
Alcohol, clinical & experimental research · 2026 Jul · DOI: 10.1111/acer.70374
Refractory Uterine Atony After Sequential Neuraxial Opioid Administration-A Case Report.
Reports (MDPI) · 2026 Jul 15 · DOI: 10.3390/reports9030227
MDMA as an early post-trauma intervention in a translational animal model of PTSD.
Progress in neuro-psychopharmacology & biological psychiatry · 2026 Jul 24 · DOI: 10.1016/j.pnpbp.2026.111853
Nucleus accumbens oxytocin modulates avoidance-related behaviors following social isolation in prairie voles.
Neuropharmacology · 2026 Jul 24 · DOI: 10.1016/j.neuropharm.2026.111113
Oral Misoprostol Versus Vaginal Dinoprostone for Labor Induction: A Systematic Review and Meta-Analysis.
The journal of obstetrics and gynaecology research · 2026 Aug · DOI: 10.1111/jog.70369
Decoding the Oxytocinergic and Behavioral Signatures of Milk Ejection.
Neuroscience bulletin · 2026 Jul 25 · DOI: 10.1007/s12264-026-01679-2
The Neural Distribution of Vasotocin, Oxytocin, Dopamine, and Serotonin in Two Australian Skinks With Contrasting Social Lives.
The Journal of comparative neurology · 2026 Jul · DOI: 10.1002/cne.70184
Association between salivary oxytocin concentration and social loneliness in older adults: Findings from an uncontrolled pre-post multimodal intervention study.
Psychoneuroendocrinology · 2026 Jul 20 · DOI: 10.1016/j.psyneuen.2026.107968
Prevention and management of postpartum hemorrhage and hypertensive disorders of pregnancy: results from a 31-country rapid assessment.
BMC pregnancy and childbirth · 2026 Jul 20 · DOI: 10.1186/s12884-026-09679-w
Verification of the lactogenic effect of egg white peptides: regulation of key proteins involved in milk synthesis.
Journal of the science of food and agriculture · 2026 Jul 20 · DOI: 10.1002/jsfa.70915
Effect of oral calcium carbonate on uterine contractility: a pilot randomised controlled trial.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2026 Dec · DOI: 10.1080/01443615.2026.2697258
Network meta-analysis of tocolytics in preterm labor: Establishing an evidence-based treatment hierarchy.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026 Jul 22 · DOI: 10.1002/ijgo.71134
An in vitro investigation on the effects of neonicotinoid pesticides on uterine contractility.
International journal of environmental health research · 2026 Jul 22 · DOI: 10.1080/09603123.2026.2702518
Carbetocin in the Prevention of Postpartum Hemorrhage after Vaginal Birth: A Systematic Review and Meta-Analysis.
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026 Jul · DOI: 10.1097/FM9.0000000000000337
Third-stage uterotonic management after second-trimester induction of labour: a retrospective cohort study.
European journal of obstetrics, gynecology, and reproductive biology · 2026 Jul 18 · DOI: 10.1016/j.ejogrb.2026.115322
Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome: Results From the Randomized, Placebo-Controlled, Phase 3 Compass PWS Study.
Clinical therapeutics · 2026 Jul 22 · DOI: 10.1016/j.clinthera.2026.06.019
Oxytocin as a regulator of skeletal muscle plasticity and metabolic function.
Frontiers in endocrinology · 2026 · DOI: 10.3389/fendo.2026.1863901
The neural and physiological mechanisms of Animal-Assisted Interventions (AAI): A systematic review and integrated framework.
Comprehensive psychoneuroendocrinology · 2026 Aug · DOI: 10.1016/j.cpnec.2026.100367
Refractory Uterine Atony After Sequential Neuraxial Opioid Administration-A Case Report.
Reports (MDPI) · 2026 Jul 15 · DOI: 10.3390/reports9030227
MDMA as an early post-trauma intervention in a translational animal model of PTSD.
Progress in neuro-psychopharmacology & biological psychiatry · 2026 Jul 24 · DOI: 10.1016/j.pnpbp.2026.111853
Nucleus accumbens oxytocin modulates avoidance-related behaviors following social isolation in prairie voles.
Neuropharmacology · 2026 Jul 24 · DOI: 10.1016/j.neuropharm.2026.111113