Effect of Liraglutide on Body Weight in Obese Subjects
Phase 3 · COMPLETED · Started 2011
Evidence Explorer
Clinical trials and publications sourced from ClinicalTrials.gov, PubMed, and FDA. Updated hourly by the automated crawler.
Verified evidence (7)
Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
PubMed publication · Published 2016
Retatrutide in Participants With Obesity
Phase 2 · COMPLETED · Started 2021
Efficacy and Safety of Semaglutide Once-Weekly Versus Placebo
Phase 3 · COMPLETED · Started 2014
STEP 1: Semaglutide for Weight Management
Phase 3 · COMPLETED · Started 2018
Tirzepatide Versus Semaglutide Once Weekly in T2D
Phase 3 · COMPLETED · Started 2019
Tirzepatide in Participants With Obesity
Phase 3 · COMPLETED · Started 2019
ClinicalTrials.gov (11)
Efficacy, Safety, and Treatment Satisfaction of Once-Weekly Tirzepatide in Obese Type 2 Diabetic Patients
Phase NA · NOT_YET_RECRUITING · Sponsor: Akhtar Saeed Medical and Dental College
Pragmatic Trial to Study the Cost-Effectiveness of MyPhenome-RX Test to Guide Anti-Obesity Pharmacotherapy
Phase NA · NOT_YET_RECRUITING · Sponsor: Phenomix Sciences
A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer
Phase PHASE2 · NOT_YET_RECRUITING · Sponsor: National Cancer Institute (NCI)
Oxytocin to Enhance Integrated Treatment for AUD and PTSD
Phase PHASE2 · COMPLETED · Sponsor: Medical University of South Carolina
Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening
Phase PHASE3 · RECRUITING · Sponsor: University Hospital, Tours
Mind-Body Group Interventions for Psychological Distress in Young Breast Cancer Survivors
Phase NA · NOT_YET_RECRUITING · Sponsor: University of Alabama at Birmingham
Evaluation of Comprehensive Emergency Obstetric and Neonatal Care Program in Malawi
Phase N/A · NOT_YET_RECRUITING · Sponsor: CDC Foundation
Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists
Phase N/A · RECRUITING · Sponsor: Ohio State University
GLP-1R Agonist Treatment for Opioid Use Disorder
Phase PHASE2 · RECRUITING · Sponsor: Milton S. Hershey Medical Center
A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity
Phase PHASE2 · RECRUITING · Sponsor: Antag Therapeutics
MODERN-Dental: Pediatric Obesity, Cardiometabolic Risks, And Periodontal Disease
Phase NA · NOT_YET_RECRUITING · Sponsor: Oelisoa Andriankaja
PubMed (89)
A Cost-Effectiveness Model of Semaglutide 2.4 mg, Resmetirom 80 mg, and Resmetirom 100 mg Versus Standard of Care for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis in the United States.
PharmacoEconomics · 2026 Jul 26 · DOI: 10.1007/s40273-026-01647-8
Efficacy of CagriSema for Reaching Anthropometric Treatment Targets and Cardiometabolic Outcomes: A Secondary, Post hoc Analysis of REDEFINE 1.
Diabetes, obesity & metabolism · 2026 Jul 26 · DOI: 10.1111/dom.71134
Metabolic control of renal cell fate in kidney disease: nutrient rewiring, senescence and fibrosis.
Metabolism: clinical and experimental · 2026 Jul 26 · DOI: 10.1016/j.metabol.2026.156714
Engineering alanine dehydrogenase to favor nicotinamide cytosine dinucleotide for formate-driven alanine synthesis.
International journal of biological macromolecules · 2026 Jul 26 · DOI: 10.1016/j.ijbiomac.2026.153769
Synthesis, Characterization, and Fluorescence Application of Indole-Based Isofunctional NAD(+) Analogs.
Chembiochem : a European journal of chemical biology · 2026 Jul 29 · DOI: 10.1002/cbic.202500797
Oral Misoprostol Versus Vaginal Dinoprostone for Labor Induction: A Systematic Review and Meta-Analysis.
The journal of obstetrics and gynaecology research · 2026 Aug · DOI: 10.1111/jog.70369
Autophagy-Related Gene-Set Signals in the Genetic Architecture of Obsessive-Compulsive Disorder: A Hypothesis-Generating Link to Nicotinamide Adenine Dinucleotide-Associated Cellular Maintenance Biology.
Cureus · 2026 Jul · DOI: 10.7759/cureus.113327
Tracing NAD(+) metabolism uncovers adaptive coordination between host and microbiome during colitis.
Cell reports · 2026 Jul 25 · DOI: 10.1016/j.celrep.2026.117730
Molecular mechanism of CtBP1-S/BARS-driven membrane fission and its cellular control by metabolic ligands.
Science advances · 2026 Jul 24 · DOI: 10.1126/sciadv.aee0624
Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism.
Acta neuropathologica · 2026 Jul 23 · DOI: 10.1007/s00401-026-03048-9
Comparison between liraglutide and dulaglutide on the incidence or progression of eye and kidney complications.
Journal of diabetes investigation · 2026 Jul 25 · DOI: 10.1111/jdi.70407
Therapeutic role of semaglutide in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis: A systematic review and meta-analysis of placebo-controlled trials with GRADE evidence assessment.
Medicine · 2026 Jul 24 · DOI: 10.1097/MD.0000000000049916
Beyond Weight Loss: Early Real-World Evidence of Semaglutide in Obesity.
Medicines (Basel, Switzerland) · 2026 Jun 28 · DOI: 10.3390/medicines13030021
Comparative effectiveness of Chinese herbal medicine versus liraglutide for weight loss in adults with obesity: A 12-month real-world target trial emulation study.
Integrative medicine research · 2026 Sep · DOI: 10.1016/j.imr.2026.101291
Comparison between liraglutide and dulaglutide on the incidence or progression of eye and kidney complications.
Journal of diabetes investigation · 2026 Jul 25 · DOI: 10.1111/jdi.70407
Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism.
Nature metabolism · 2026 Jul 24 · DOI: 10.1038/s42255-026-01575-z
Effects of glucagon-like peptide-1 receptor agonists on metabolic outcomes in antipsychotic-treated patients with schizophrenia: A systematic review and meta-analysis.
Schizophrenia research · 2026 Jul 24 · DOI: 10.1016/j.schres.2026.06.025
Circulating levels of PYY are increased in individuals with bile acid diarrhoea.
The Journal of clinical endocrinology and metabolism · 2026 Jul 24 · DOI: 10.1210/clinem/dgag295
Semaglutide vs. liraglutide and incidence of diabetes and cardiovascular disease: A target trial emulation using real-world data.
British journal of clinical pharmacology · 2026 Jul 16 · DOI: 10.1002/bcp.70711
Tirzepatide and the gut microbiota-obesity axis: metabolic mechanisms and therapeutic perspectives.
Frontiers in microbiology · 2026 · DOI: 10.3389/fmicb.2026.1901528
Papular granuloma annulare associated with tirzepatide: A case report.
JAAD case reports · 2026 Aug · DOI: 10.1016/j.jdcr.2026.06.046
Tirzepatide-Induced Weight Loss and Exacerbation of Bipolar Disorder With Clozapine Treatment: A Case Report.
Journal of clinical psychopharmacology · 2026 Jul 24 · DOI: 10.1097/JCP.0000000000002241
Real-world treatment satisfaction and experience with once-weekly tirzepatide: Insights from prescribing physicians and people with obesity or overweight.
Obesity pillars · 2026 Sep · DOI: 10.1016/j.obpill.2026.100300
Comparative Efficacy and Safety of Tirzepatide in Asian and Non-Asian Adults With Obesity Without Diabetes: A Systematic Review and Meta-Analysis.
Endocrinology, diabetes & metabolism · 2026 Jul · DOI: 10.1002/edm2.70291
GLP-1 Receptor Agonists and All-Cause Overdose Risk in Veterans With Type 2 Diabetes and Opioid Use Disorder.
The Journal of clinical psychiatry · 2026 Jul 15 · DOI: 10.4088/JCP.25m16212
Coronary artery disease -related outcomes associated with semaglutide and tirzepatide in type 2 diabetes mellitus and obesity: a systematic review and meta-analysis.
Nutrition, metabolism, and cardiovascular diseases : NMCD · 2026 Jul 7 · DOI: 10.1016/j.numecd.2026.104859
Hyperuricemia, gout and obesity: should weight management be more of a focus in gout management?
Nutrition, metabolism, and cardiovascular diseases : NMCD · 2026 Jul 9 · DOI: 10.1016/j.numecd.2026.104860
Postshortage Compounded GLP-1 RA Market in 2 States With Potentially High Demand.
JAMA health forum · 2026 Jul 2 · DOI: 10.1001/jamahealthforum.2026.2207
Obese and overweight patients with type 2 diabetes mellitus are not treated optimally - an overview of current clinical practice and future perspectives.
Expert review of clinical pharmacology · 2026 Jul 21 · DOI: 10.1080/17512433.2026.2706660
Evolving utilization of bariatric surgery since the rise of semaglutide and tirzepatide.
Surgical endoscopy · 2026 Jul 17 · DOI: 10.1007/s00464-026-13147-z
Comparative Cardiovascular Outcomes of Tirzepatide and Glucagon-Like Peptide-1 Receptor Agonists in Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease.
Journal of the American Heart Association · 2026 Jul 17 · DOI: 10.1161/JAHA.125.047018
Urological Complications of Morbid Obesity and the Role of Bariatric Surgery and Glucagon-Like Peptide-1 Receptor Agonists in Their Management: A Systematic Review.
Cureus · 2026 Jun · DOI: 10.7759/cureus.110952
Tirzepatide as a therapeutic tool for kidney impairment in obesity: insights from a real-world study.
Journal of translational medicine · 2026 Jul 16 · DOI: 10.1186/s12967-026-08558-4
Effect of short-term tirzepatide treatment on mean platelet volume in patients with obesity: a retrospective controlled study.
BMC endocrine disorders · 2026 Jul 16 · DOI: 10.1186/s12902-026-02422-8
Decoding the Oxytocinergic and Behavioral Signatures of Milk Ejection.
Neuroscience bulletin · 2026 Jul 25 · DOI: 10.1007/s12264-026-01679-2
Oral Misoprostol Versus Vaginal Dinoprostone for Labor Induction: A Systematic Review and Meta-Analysis.
The journal of obstetrics and gynaecology research · 2026 Aug · DOI: 10.1111/jog.70369
Nucleus accumbens oxytocin modulates avoidance-related behaviors following social isolation in prairie voles.
Neuropharmacology · 2026 Jul 24 · DOI: 10.1016/j.neuropharm.2026.111113
MDMA as an early post-trauma intervention in a translational animal model of PTSD.
Progress in neuro-psychopharmacology & biological psychiatry · 2026 Jul 24 · DOI: 10.1016/j.pnpbp.2026.111853
Refractory Uterine Atony After Sequential Neuraxial Opioid Administration-A Case Report.
Reports (MDPI) · 2026 Jul 15 · DOI: 10.3390/reports9030227
Intranasal Vasopressin Decreases Voluntary Ethanol Drinking in Single- and Group-Housed Mice Through Mechanisms Involving Vasopressin 1a and 1b Receptors.
Alcohol, clinical & experimental research · 2026 Jul · DOI: 10.1111/acer.70374
Plasticity of subfornical organ astrocyte structure and supraoptic nucleus hormone expression following extreme dehydration in the desert rodent Gerbillus tarabuli.
Journal of neuroendocrinology · 2026 Jul · DOI: 10.1111/jne.70236
The Effects of Oxytocin on Stressed Rats with Increased Urinary Frequency.
International neurourology journal · 2026 Jul 17 · DOI: 10.5213/inj.2550358.179
Late-pregnancy oxytocin alleviates neuroinflammation and hyperalgesia in chronic migraine model via PVN to NTS oxytocinergic projections and ECM-receptor interaction signaling.
Brain, behavior, and immunity · 2026 Jul 19 · DOI: 10.1016/j.bbi.2026.106919
Comparative efficacy of pharmacological, adjunctive, and non-pharmacological interventions across behavioral domains in children and adolescents with autism spectrum disorder: a network meta-analysis.
Child and adolescent psychiatry and mental health · 2026 Jul 17 · DOI: 10.1186/s13034-026-01132-2
Maturation of social adaptation circuits from ontogeny to pathology.
Neuroscience and biobehavioral reviews · 2026 Jul 17 · DOI: 10.1016/j.neubiorev.2026.106874
Progesterone regulates the secretion of GnRH in bovine endometrial cells via the Erk1/2-ARRB1 pathway.
Theriogenology · 2026 Jul 16 · DOI: 10.1016/j.theriogenology.2026.118079
Comprehensive characterization of bremelanotide acetate and its degradants by LC-HRMS/MS and predicting epimerization through computational modelling.
Analytical methods : advancing methods and applications · 2026 Jul 22 · DOI: 10.1039/d6ay01098a
Exercise-induced redox modulation of red blood cell function in health and disease: Mechanistic implications for hemoglobin cycling and microvascular regulation.
Microvascular research · 2026 Jul 24 · DOI: 10.1016/j.mvr.2026.104991
Effects of glucagon-like peptide-1 receptor agonists on metabolic outcomes in antipsychotic-treated patients with schizophrenia: A systematic review and meta-analysis.
Schizophrenia research · 2026 Jul 24 · DOI: 10.1016/j.schres.2026.06.025
Beyond Weight Loss: Early Real-World Evidence of Semaglutide in Obesity.
Medicines (Basel, Switzerland) · 2026 Jun 28 · DOI: 10.3390/medicines13030021
Comparison of lifestyle, surgery, and semaglutide for weight management in endometrial cancer: a prospective observational study.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2026 Dec · DOI: 10.1080/01443615.2026.2701996
Efficacy and Safety of Once-Weekly Semaglutide Versus Basal Insulin and Other GLP-1 Receptor Agonists in Adults With Type 2 Diabetes Uncontrolled on Oral Antidiabetic Drugs: A Systematic Review and Pairwise Meta-Analysis.
Cureus · 2026 Jun · DOI: 10.7759/cureus.111363
Evaluating the Cardiovascular Benefits of Innovator Semaglutide 2.4 mg (Recombinant DNA (r-DNA)) in Patients With Overweight or Obesity: A Critical Review of Current Evidence.
Cureus · 2026 Jun · DOI: 10.7759/cureus.111322
Nucleus accumbens oxytocin modulates avoidance-related behaviors following social isolation in prairie voles.
Neuropharmacology · 2026 Jul 24 · DOI: 10.1016/j.neuropharm.2026.111113
MDMA as an early post-trauma intervention in a translational animal model of PTSD.
Progress in neuro-psychopharmacology & biological psychiatry · 2026 Jul 24 · DOI: 10.1016/j.pnpbp.2026.111853
Refractory Uterine Atony After Sequential Neuraxial Opioid Administration-A Case Report.
Reports (MDPI) · 2026 Jul 15 · DOI: 10.3390/reports9030227
The neural and physiological mechanisms of Animal-Assisted Interventions (AAI): A systematic review and integrated framework.
Comprehensive psychoneuroendocrinology · 2026 Aug · DOI: 10.1016/j.cpnec.2026.100367
Oxytocin as a regulator of skeletal muscle plasticity and metabolic function.
Frontiers in endocrinology · 2026 · DOI: 10.3389/fendo.2026.1863901
Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi Syndrome: Results From the Randomized, Placebo-Controlled, Phase 3 Compass PWS Study.
Clinical therapeutics · 2026 Jul 22 · DOI: 10.1016/j.clinthera.2026.06.019
Third-stage uterotonic management after second-trimester induction of labour: a retrospective cohort study.
European journal of obstetrics, gynecology, and reproductive biology · 2026 Jul 18 · DOI: 10.1016/j.ejogrb.2026.115322
Carbetocin in the Prevention of Postpartum Hemorrhage after Vaginal Birth: A Systematic Review and Meta-Analysis.
Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026 Jul · DOI: 10.1097/FM9.0000000000000337
An in vitro investigation on the effects of neonicotinoid pesticides on uterine contractility.
International journal of environmental health research · 2026 Jul 22 · DOI: 10.1080/09603123.2026.2702518
Network meta-analysis of tocolytics in preterm labor: Establishing an evidence-based treatment hierarchy.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026 Jul 22 · DOI: 10.1002/ijgo.71134
Effect of oral calcium carbonate on uterine contractility: a pilot randomised controlled trial.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2026 Dec · DOI: 10.1080/01443615.2026.2697258
Verification of the lactogenic effect of egg white peptides: regulation of key proteins involved in milk synthesis.
Journal of the science of food and agriculture · 2026 Jul 20 · DOI: 10.1002/jsfa.70915
Prevention and management of postpartum hemorrhage and hypertensive disorders of pregnancy: results from a 31-country rapid assessment.
BMC pregnancy and childbirth · 2026 Jul 20 · DOI: 10.1186/s12884-026-09679-w
Association between salivary oxytocin concentration and social loneliness in older adults: Findings from an uncontrolled pre-post multimodal intervention study.
Psychoneuroendocrinology · 2026 Jul 20 · DOI: 10.1016/j.psyneuen.2026.107968
The Neural Distribution of Vasotocin, Oxytocin, Dopamine, and Serotonin in Two Australian Skinks With Contrasting Social Lives.
The Journal of comparative neurology · 2026 Jul · DOI: 10.1002/cne.70184
Exercise-induced redox modulation of red blood cell function in health and disease: Mechanistic implications for hemoglobin cycling and microvascular regulation.
Microvascular research · 2026 Jul 24 · DOI: 10.1016/j.mvr.2026.104991
Molecular mechanism of CtBP1-S/BARS-driven membrane fission and its cellular control by metabolic ligands.
Science advances · 2026 Jul 24 · DOI: 10.1126/sciadv.aee0624
Anterior cervical osteophyte-related dysphagia in a long-term growth hormone user: a case report.
Frontiers in surgery · 2026 · DOI: 10.3389/fsurg.2026.1859548
Retatrutide and the urinary tract infection signal: Is the answer hidden in timing?
European journal of internal medicine · 2026 Jul 23 · DOI: 10.1016/j.ejim.2026.107099
The Role of Oxidative Stress in Heart Failure: Mechanisms and Therapeutic Targets.
Cureus · 2026 Jun · DOI: 10.7759/cureus.111384
Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism.
Acta neuropathologica · 2026 Jul 23 · DOI: 10.1007/s00401-026-03048-9
Targeting the NAD(+) salvage pathway: Identification of bifunctional NAMPT inhibitors and SIRT1 activators through pharmacophore-based virtual screening.
Bioorganic & medicinal chemistry · 2026 Jul 19 · DOI: 10.1016/j.bmc.2026.118754
Circulating levels of PYY are increased in individuals with bile acid diarrhoea.
The Journal of clinical endocrinology and metabolism · 2026 Jul 24 · DOI: 10.1210/clinem/dgag295
Efficacy and Safety of Once-Weekly Semaglutide Versus Basal Insulin and Other GLP-1 Receptor Agonists in Adults With Type 2 Diabetes Uncontrolled on Oral Antidiabetic Drugs: A Systematic Review and Pairwise Meta-Analysis.
Cureus · 2026 Jun · DOI: 10.7759/cureus.111363
A survey of primary care physicians' views on supporting patients who lose insurance coverage for Glucagon-Like Peptide-1-based drugs for weight management.
Obesity pillars · 2026 Sep · DOI: 10.1016/j.obpill.2026.100304
Clinical efficacy of liraglutide combined with pioglitazone in obese polycystic ovary syndrome and its effects on the serum chemerin/visfatin ratio.
American journal of translational research · 2026 · DOI: 10.62347/WNDZ4386
GLP-1 receptor agonists in Parkinson's disease: a meta-analysis revealing motor benefit and highlighting mood improvement.
Frontiers in neurology · 2026 · DOI: 10.3389/fneur.2026.1858507
Weight Loss Following Liraglutide Therapy in a Patient With Smith-Magenis Syndrome: A Case Report.
Cureus · 2026 Jun · DOI: 10.7759/cureus.111313
Pharmacologic Treatments for MASLD: A Review of Efficacy and Safety Considerations.
The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2026 Jul 20 · DOI: 10.1177/87551225261466571
Glucagon-Like Peptide-1 Receptor Agonists in Orthopedics: A Scoping Review of Emerging Applications.
Indian journal of orthopaedics · 2026 Jul · DOI: 10.1007/s43465-025-01614-z
Safety Signals of GLP-1 Receptor Agonists: A Multi-Method Pharmacovigilance Analysis of FAERS (2018-2025) With Sensitivity-Stratified Prioritisation, Notoriety-Bias Assessment, and Cross-Database Validation.
Diabetes, obesity & metabolism · 2026 Jul 21 · DOI: 10.1111/dom.71138
GLP-1 Receptor Agonists as a Candidate Treatment for Opioid Use Disorder: From rats to humans.
Biological psychiatry · 2026 Jul 21 · DOI: 10.1016/j.biopsych.2026.06.033
A systematic review and meta-analyses of glucagon-like peptide-1 receptor agonists in acute myocardial infarction.
The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026 Jul 21 · DOI: 10.1186/s43044-026-00767-y
Respiratory Adverse Events of Weight-Loss Drugs: A Systematic Review and Meta-Analysis.
Annals of the American Thoracic Society · 2026 Jul 21 · DOI: 10.1093/annalsats/aaoag177
GLP-1 receptor agonists in multiple sclerosis: a systematic review of preclinical and clinical evidence.
Multiple sclerosis and related disorders · 2026 Jul 10 · DOI: 10.1016/j.msard.2026.107388
Synergistic cardioprotection by liraglutide and deferoxamine against doxorubicin-induced cardiotoxicity via modulation of ACSL-4/Nrf-2/GPX-4 signaling.
Naunyn-Schmiedeberg's archives of pharmacology · 2026 Jul 18 · DOI: 10.1007/s00210-026-05646-6