CompoundedGuide

Regulatory Status Updates

Live feed of FDA, ClinicalTrials.gov, and PubMed changes affecting tracked peptides. Automatically updated hourly.

ClinicalTrials.gov New record

A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer

Phase PHASE2 · NOT_YET_RECRUITING · Sponsor: National Cancer Institute (NCI)

Affected record: tirzepatide · ID: NCT07349641
ClinicalTrials.gov New record

Pragmatic Trial to Study the Cost-Effectiveness of MyPhenome-RX Test to Guide Anti-Obesity Pharmacotherapy

Phase NA · NOT_YET_RECRUITING · Sponsor: Phenomix Sciences

Affected record: tirzepatide · ID: NCT07728812
ClinicalTrials.gov New record

Efficacy, Safety, and Treatment Satisfaction of Once-Weekly Tirzepatide in Obese Type 2 Diabetic Patients

Phase NA · NOT_YET_RECRUITING · Sponsor: Akhtar Saeed Medical and Dental College

Affected record: tirzepatide · ID: NCT07728318
ClinicalTrials.gov New record

Evaluation of Comprehensive Emergency Obstetric and Neonatal Care Program in Malawi

Phase N/A · NOT_YET_RECRUITING · Sponsor: CDC Foundation

Affected record: oxytocin · ID: NCT07727928
ClinicalTrials.gov New record

Mind-Body Group Interventions for Psychological Distress in Young Breast Cancer Survivors

Phase NA · NOT_YET_RECRUITING · Sponsor: University of Alabama at Birmingham

Affected record: oxytocin · ID: NCT07501637
ClinicalTrials.gov New record

Oxytocin vs Prostaglandins for Labor Induction of Women With an Unfavorable Cervix After 24h of Cervical Ripening

Phase PHASE3 · RECRUITING · Sponsor: University Hospital, Tours

Affected record: oxytocin · ID: NCT04949633
ClinicalTrials.gov Status change

Oxytocin to Enhance Integrated Treatment for AUD and PTSD

Phase PHASE2 · COMPLETED · Sponsor: Medical University of South Carolina

Affected record: oxytocin · ID: NCT04523922
PubMed New record

Efficacy of CagriSema for Reaching Anthropometric Treatment Targets and Cardiometabolic Outcomes: A Secondary, Post hoc Analysis of REDEFINE 1.

Diabetes, obesity & metabolism · 2026 Jul 26 · DOI: 10.1111/dom.71134

Affected record: semaglutide · ID: 42503495
PubMed New record

A Cost-Effectiveness Model of Semaglutide 2.4 mg, Resmetirom 80 mg, and Resmetirom 100 mg Versus Standard of Care for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis in the United States.

PharmacoEconomics · 2026 Jul 26 · DOI: 10.1007/s40273-026-01647-8

Affected record: semaglutide · ID: 42503575
PubMed New record

Synthesis, Characterization, and Fluorescence Application of Indole-Based Isofunctional NAD(+) Analogs.

Chembiochem : a European journal of chemical biology · 2026 Jul 29 · DOI: 10.1002/cbic.202500797

Affected record: nad-plus · ID: 42503180
PubMed New record

Engineering alanine dehydrogenase to favor nicotinamide cytosine dinucleotide for formate-driven alanine synthesis.

International journal of biological macromolecules · 2026 Jul 26 · DOI: 10.1016/j.ijbiomac.2026.153769

Affected record: nad-plus · ID: 42503384
PubMed New record

Metabolic control of renal cell fate in kidney disease: nutrient rewiring, senescence and fibrosis.

Metabolism: clinical and experimental · 2026 Jul 26 · DOI: 10.1016/j.metabol.2026.156714

Affected record: nad-plus · ID: 42503404
PubMed New record

Oral Misoprostol Versus Vaginal Dinoprostone for Labor Induction: A Systematic Review and Meta-Analysis.

The journal of obstetrics and gynaecology research · 2026 Aug · DOI: 10.1111/jog.70369

Affected record: oxytocin · ID: 42499212
PubMed New record

Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism.

Acta neuropathologica · 2026 Jul 23 · DOI: 10.1007/s00401-026-03048-9

Affected record: nad-plus · ID: 42493667
PubMed New record

Molecular mechanism of CtBP1-S/BARS-driven membrane fission and its cellular control by metabolic ligands.

Science advances · 2026 Jul 24 · DOI: 10.1126/sciadv.aee0624

Affected record: nad-plus · ID: 42497255
PubMed New record

Tracing NAD(+) metabolism uncovers adaptive coordination between host and microbiome during colitis.

Cell reports · 2026 Jul 25 · DOI: 10.1016/j.celrep.2026.117730

Affected record: nad-plus · ID: 42501334
PubMed New record

Autophagy-Related Gene-Set Signals in the Genetic Architecture of Obsessive-Compulsive Disorder: A Hypothesis-Generating Link to Nicotinamide Adenine Dinucleotide-Associated Cellular Maintenance Biology.

Cureus · 2026 Jul · DOI: 10.7759/cureus.113327

Affected record: nad-plus · ID: 42502305
PubMed New record

Comparison between liraglutide and dulaglutide on the incidence or progression of eye and kidney complications.

Journal of diabetes investigation · 2026 Jul 25 · DOI: 10.1111/jdi.70407

Affected record: liraglutide · ID: 42499272
PubMed New record

Beyond Weight Loss: Early Real-World Evidence of Semaglutide in Obesity.

Medicines (Basel, Switzerland) · 2026 Jun 28 · DOI: 10.3390/medicines13030021

Affected record: semaglutide · ID: 42496290
PubMed New record

Therapeutic role of semaglutide in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis: A systematic review and meta-analysis of placebo-controlled trials with GRADE evidence assessment.

Medicine · 2026 Jul 24 · DOI: 10.1097/MD.0000000000049916

Affected record: semaglutide · ID: 42499082
PubMed New record

Semaglutide vs. liraglutide and incidence of diabetes and cardiovascular disease: A target trial emulation using real-world data.

British journal of clinical pharmacology · 2026 Jul 16 · DOI: 10.1002/bcp.70711

Affected record: liraglutide · ID: 42464447
PubMed New record

Circulating levels of PYY are increased in individuals with bile acid diarrhoea.

The Journal of clinical endocrinology and metabolism · 2026 Jul 24 · DOI: 10.1210/clinem/dgag295

Affected record: liraglutide · ID: 42496159
PubMed New record

Effects of glucagon-like peptide-1 receptor agonists on metabolic outcomes in antipsychotic-treated patients with schizophrenia: A systematic review and meta-analysis.

Schizophrenia research · 2026 Jul 24 · DOI: 10.1016/j.schres.2026.06.025

Affected record: liraglutide · ID: 42497473
PubMed New record

Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism.

Nature metabolism · 2026 Jul 24 · DOI: 10.1038/s42255-026-01575-z

Affected record: liraglutide · ID: 42498824
PubMed New record

Comparison between liraglutide and dulaglutide on the incidence or progression of eye and kidney complications.

Journal of diabetes investigation · 2026 Jul 25 · DOI: 10.1111/jdi.70407

Affected record: liraglutide · ID: 42499272
PubMed New record

Comparative effectiveness of Chinese herbal medicine versus liraglutide for weight loss in adults with obesity: A 12-month real-world target trial emulation study.

Integrative medicine research · 2026 Sep · DOI: 10.1016/j.imr.2026.101291

Affected record: liraglutide · ID: 42500463
PubMed New record

Effect of short-term tirzepatide treatment on mean platelet volume in patients with obesity: a retrospective controlled study.

BMC endocrine disorders · 2026 Jul 16 · DOI: 10.1186/s12902-026-02422-8

Affected record: tirzepatide · ID: 42464179
PubMed New record

Tirzepatide as a therapeutic tool for kidney impairment in obesity: insights from a real-world study.

Journal of translational medicine · 2026 Jul 16 · DOI: 10.1186/s12967-026-08558-4

Affected record: tirzepatide · ID: 42464302
PubMed New record

Urological Complications of Morbid Obesity and the Role of Bariatric Surgery and Glucagon-Like Peptide-1 Receptor Agonists in Their Management: A Systematic Review.

Cureus · 2026 Jun · DOI: 10.7759/cureus.110952

Affected record: tirzepatide · ID: 42465136
PubMed New record

Comparative Cardiovascular Outcomes of Tirzepatide and Glucagon-Like Peptide-1 Receptor Agonists in Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease.

Journal of the American Heart Association · 2026 Jul 17 · DOI: 10.1161/JAHA.125.047018

Affected record: tirzepatide · ID: 42466510
PubMed New record

Evolving utilization of bariatric surgery since the rise of semaglutide and tirzepatide.

Surgical endoscopy · 2026 Jul 17 · DOI: 10.1007/s00464-026-13147-z

Affected record: tirzepatide · ID: 42467193
PubMed New record

Obese and overweight patients with type 2 diabetes mellitus are not treated optimally - an overview of current clinical practice and future perspectives.

Expert review of clinical pharmacology · 2026 Jul 21 · DOI: 10.1080/17512433.2026.2706660

Affected record: tirzepatide · ID: 42467408
PubMed New record

Postshortage Compounded GLP-1 RA Market in 2 States With Potentially High Demand.

JAMA health forum · 2026 Jul 2 · DOI: 10.1001/jamahealthforum.2026.2207

Affected record: tirzepatide · ID: 42467450
PubMed New record

Hyperuricemia, gout and obesity: should weight management be more of a focus in gout management?

Nutrition, metabolism, and cardiovascular diseases : NMCD · 2026 Jul 9 · DOI: 10.1016/j.numecd.2026.104860

Affected record: tirzepatide · ID: 42469142
PubMed New record

Coronary artery disease -related outcomes associated with semaglutide and tirzepatide in type 2 diabetes mellitus and obesity: a systematic review and meta-analysis.

Nutrition, metabolism, and cardiovascular diseases : NMCD · 2026 Jul 7 · DOI: 10.1016/j.numecd.2026.104859

Affected record: tirzepatide · ID: 42469143
PubMed New record

GLP-1 Receptor Agonists and All-Cause Overdose Risk in Veterans With Type 2 Diabetes and Opioid Use Disorder.

The Journal of clinical psychiatry · 2026 Jul 15 · DOI: 10.4088/JCP.25m16212

Affected record: tirzepatide · ID: 42474323
PubMed New record

Comparative Efficacy and Safety of Tirzepatide in Asian and Non-Asian Adults With Obesity Without Diabetes: A Systematic Review and Meta-Analysis.

Endocrinology, diabetes & metabolism · 2026 Jul · DOI: 10.1002/edm2.70291

Affected record: tirzepatide · ID: 42487213
PubMed New record

Real-world treatment satisfaction and experience with once-weekly tirzepatide: Insights from prescribing physicians and people with obesity or overweight.

Obesity pillars · 2026 Sep · DOI: 10.1016/j.obpill.2026.100300

Affected record: tirzepatide · ID: 42491427
PubMed New record

Tirzepatide-Induced Weight Loss and Exacerbation of Bipolar Disorder With Clozapine Treatment: A Case Report.

Journal of clinical psychopharmacology · 2026 Jul 24 · DOI: 10.1097/JCP.0000000000002241

Affected record: tirzepatide · ID: 42495981
PubMed New record

Papular granuloma annulare associated with tirzepatide: A case report.

JAAD case reports · 2026 Aug · DOI: 10.1016/j.jdcr.2026.06.046

Affected record: tirzepatide · ID: 42499401
PubMed New record

Tirzepatide and the gut microbiota-obesity axis: metabolic mechanisms and therapeutic perspectives.

Frontiers in microbiology · 2026 · DOI: 10.3389/fmicb.2026.1901528

Affected record: tirzepatide · ID: 42499664
PubMed New record

Progesterone regulates the secretion of GnRH in bovine endometrial cells via the Erk1/2-ARRB1 pathway.

Theriogenology · 2026 Jul 16 · DOI: 10.1016/j.theriogenology.2026.118079

Affected record: oxytocin · ID: 42468499
PubMed New record

Maturation of social adaptation circuits from ontogeny to pathology.

Neuroscience and biobehavioral reviews · 2026 Jul 17 · DOI: 10.1016/j.neubiorev.2026.106874

Affected record: oxytocin · ID: 42468814
PubMed New record

Comparative efficacy of pharmacological, adjunctive, and non-pharmacological interventions across behavioral domains in children and adolescents with autism spectrum disorder: a network meta-analysis.

Child and adolescent psychiatry and mental health · 2026 Jul 17 · DOI: 10.1186/s13034-026-01132-2

Affected record: oxytocin · ID: 42469874
PubMed New record

Late-pregnancy oxytocin alleviates neuroinflammation and hyperalgesia in chronic migraine model via PVN to NTS oxytocinergic projections and ECM-receptor interaction signaling.

Brain, behavior, and immunity · 2026 Jul 19 · DOI: 10.1016/j.bbi.2026.106919

Affected record: oxytocin · ID: 42472609
PubMed New record

The Effects of Oxytocin on Stressed Rats with Increased Urinary Frequency.

International neurourology journal · 2026 Jul 17 · DOI: 10.5213/inj.2550358.179

Affected record: oxytocin · ID: 42472624
PubMed New record

Plasticity of subfornical organ astrocyte structure and supraoptic nucleus hormone expression following extreme dehydration in the desert rodent Gerbillus tarabuli.

Journal of neuroendocrinology · 2026 Jul · DOI: 10.1111/jne.70236

Affected record: oxytocin · ID: 42472974
PubMed New record

Intranasal Vasopressin Decreases Voluntary Ethanol Drinking in Single- and Group-Housed Mice Through Mechanisms Involving Vasopressin 1a and 1b Receptors.

Alcohol, clinical & experimental research · 2026 Jul · DOI: 10.1111/acer.70374

Affected record: oxytocin · ID: 42473029
PubMed New record

Refractory Uterine Atony After Sequential Neuraxial Opioid Administration-A Case Report.

Reports (MDPI) · 2026 Jul 15 · DOI: 10.3390/reports9030227

Affected record: oxytocin · ID: 42496524
PubMed New record

MDMA as an early post-trauma intervention in a translational animal model of PTSD.

Progress in neuro-psychopharmacology & biological psychiatry · 2026 Jul 24 · DOI: 10.1016/j.pnpbp.2026.111853

Affected record: oxytocin · ID: 42498117