NAD+ — Evidence
Clinical trials and publications sourced from ClinicalTrials.gov, PubMed, and FDA. Updated hourly by the automated crawler.
Registered studies (50)
From the ClinicalTrials.gov record captured for this substance. Registration is not evidence of approval, efficacy, or safety.
Food Supplement for Longevity
A IB/II Phase Clinical Study on the Safety, Tolerability, and Efficacy of SHR-9839(sc) in Combination Anti-tumor Therapy in Patients With Solid Tumors
Effects of Ketone Supplement and Alcohol on Brain Metabolism
Analysis of Radiographic Indices in Carpal Tunnel Syndrome
Impact of NMN Supplementation on CD4+ T Cell Recovery in HIV Patients With Immunological Failure
Use of Vassopresin in Septic Shock Prospective Multicenter Observational Study With Medication
Empirical Intravenous Beta-Lactam Plus Metronidazole Vs Oral Cefixime Plus Metronidazole for the Treatment of Liver Abscess
Evaluation of Myocardial Function by Global Longitudinal Strain (GLS) Measurement in 2D Echocardiography of Patients With Fibromyalgia
Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity
The Safety and Efficacy of Coenzyme I for Injection in Promoting Hematopoietic Recovery of Patients After sUCBT
Food Replacement on Weight Control in Overweight Volunteers
Nicotinamide in Glaucoma (NAMinG): A Randomised, Placebo-controlled, Multi-centre, Phase III Trial
Oxidative Stress, Carbohydrate Metabolism Disorders and G6PD Deficiency
NAD Augmentation in Diabetes Kidney Disease
Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)
Notched Noise Therapy for Suppression of Tinnitus
PROCO Neck: The Course and Neuroplasticity in Neck Pain-Associated Disorders and Whiplash-Associated Disorders
The Study of Comparing the Efficacy and Safety of Human Umbilical Cord MSCs and Low-dose IL-2 in the Treatment of LN
RP-3500 and Olaparib in DNA Damage Repair Pathway Deficient Relapsed/Refractory Chronic Lymphocytic Leukemia
Effect of NMN (Nicotinamide Mononucleotide) on Diminished Ovarian Reserve (Including Premature Ovarian Insufficiency)
COVID-19: SARS-CoV-2-CZ-PREVAL-II Study
Melatonin on Clock Genes in Parkinson's Disease
Respiratory Muscle Fatigue at Different Breathing Modes
Empowerment Self-Defense Training for the Prevention of Victimization of Transgender Women
Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy
Evaluate the Efficacy and Safety of Uthever NMN(Nicotinamide Mononucleotide, a Form of Vitamin B3)
Mind-Body Interventions to Mitigate Effects of Media Use on Sleep in Early Adolescents
Assessment of the Hemodynamic Effect of Hydroxocabalamin in Refractory Vasodilatory Shock
NAD+ and Exercise in FA
The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS.
Biomarker-based Multidisciplinary Team (Bio-MDT) Approach to Personalized Microbial-targeted Treatment of Pouchitis and Crohn's Disease
Musculoskeletal Changes After Physiotherapeutic Intervention in Podiatric Subjects
Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
A Study by ChromaDex to Assess the Effects of TRU NIAGEN on Cognitive Function, Mood and Sleep in Older Adults
The Effects of Antipsychotic Drugs on Brain Metabolism in Healthy Individuals
Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - Coronary Intervention With Next Generation Drug-Eluting Stent Platforms and Abbreviated Dual Antiplatelet Therapy (HOST-IDEA) Trial
Lenalidomide for Adult Histiocyte Disorders
Acute Myocardial Necrosis and Depression: Antiplatelet Effect of Reuptake Inhibition of Serotonin
A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendavia™) on Skeletal Muscle Function in Elderly
Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia
Patients With Pulmonary Hypertension or Interstitial Lung Disease at Altitude - Effect of Oxygen on Breathing and Sleep
Liver and Fat Regulation in Overweight Adolescent Girls
Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Advanced Malignancies and Hepatic Impairment
A Multicenter, Open-label, Phase 1b Study of Carfilzomib, Cyclophosphamide and Dexamethasone in Newly Diagnosed Multiple Myeloma Subjects
Trial of Hypofractionated IMRT Boost Versus Conventional IMRT Boost for Localized High Risk Prostate Cancer
Efficacy of Oncoxin Plus Viusid in the Treatment of Rheumatoid Arthritis
Efficacy of Seven-day Combined Rabeprazole Plus Levofloxacin Plus Augmentin for Eradication of Helicobacter Pylori
The Muscle in Children With Cerebral Palsy - Longitudinal Exploration of Microscopic Muscle Structure.
Iron Supplementation in Heart Failure Patients With Anemia: The IRON-HF Study
ClinicalTrials.gov (7)
Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies
Phase PHASE1 · RECRUITING · Sponsor: Barbara Ann Karmanos Cancer Institute
Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans
Phase NA · ACTIVE_NOT_RECRUITING · Sponsor: VA Office of Research and Development
Changing the Natural History of Type 2 Diabetes ("CHANGE" Study)
Phase NA · ACTIVE_NOT_RECRUITING · Sponsor: Foundation for Atlanta Veterans Education and Research, Inc.
Psychosocial Mobile App for Chronic Graft-Versus-Host Disease
Phase NA · ACTIVE_NOT_RECRUITING · Sponsor: Massachusetts General Hospital
Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus
Phase PHASE1/PHASE2 · RECRUITING · Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome
Phase PHASE1 · NOT_YET_RECRUITING · Sponsor: Brigham and Women's Hospital
Gut Microbiome and Metabolic Health Study
Phase PHASE2 · RECRUITING · Sponsor: RDC Clinical Pty Ltd
PubMed (29)
Synthesis, Characterization, and Fluorescence Application of Indole-Based Isofunctional NAD(+) Analogs.
Chembiochem : a European journal of chemical biology · 2026 Jul 29 · DOI: 10.1002/cbic.202500797
Engineering alanine dehydrogenase to favor nicotinamide cytosine dinucleotide for formate-driven alanine synthesis.
International journal of biological macromolecules · 2026 Jul 26 · DOI: 10.1016/j.ijbiomac.2026.153769
Metabolic control of renal cell fate in kidney disease: nutrient rewiring, senescence and fibrosis.
Metabolism: clinical and experimental · 2026 Jul 26 · DOI: 10.1016/j.metabol.2026.156714
Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism.
Acta neuropathologica · 2026 Jul 23 · DOI: 10.1007/s00401-026-03048-9
Molecular mechanism of CtBP1-S/BARS-driven membrane fission and its cellular control by metabolic ligands.
Science advances · 2026 Jul 24 · DOI: 10.1126/sciadv.aee0624
Tracing NAD(+) metabolism uncovers adaptive coordination between host and microbiome during colitis.
Cell reports · 2026 Jul 25 · DOI: 10.1016/j.celrep.2026.117730
Autophagy-Related Gene-Set Signals in the Genetic Architecture of Obsessive-Compulsive Disorder: A Hypothesis-Generating Link to Nicotinamide Adenine Dinucleotide-Associated Cellular Maintenance Biology.
Cureus · 2026 Jul · DOI: 10.7759/cureus.113327
Exercise-induced redox modulation of red blood cell function in health and disease: Mechanistic implications for hemoglobin cycling and microvascular regulation.
Microvascular research · 2026 Jul 24 · DOI: 10.1016/j.mvr.2026.104991
Molecular mechanism of CtBP1-S/BARS-driven membrane fission and its cellular control by metabolic ligands.
Science advances · 2026 Jul 24 · DOI: 10.1126/sciadv.aee0624
Exercise-induced redox modulation of red blood cell function in health and disease: Mechanistic implications for hemoglobin cycling and microvascular regulation.
Microvascular research · 2026 Jul 24 · DOI: 10.1016/j.mvr.2026.104991
Targeting the NAD(+) salvage pathway: Identification of bifunctional NAMPT inhibitors and SIRT1 activators through pharmacophore-based virtual screening.
Bioorganic & medicinal chemistry · 2026 Jul 19 · DOI: 10.1016/j.bmc.2026.118754
Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism.
Acta neuropathologica · 2026 Jul 23 · DOI: 10.1007/s00401-026-03048-9
The Role of Oxidative Stress in Heart Failure: Mechanisms and Therapeutic Targets.
Cureus · 2026 Jun · DOI: 10.7759/cureus.111384
Plastid G6PD3 and cytosolic G6PD5/6 are involved in the Ustilago sp. HFJ311-enhanced tolerance to cadmium stress in Arabidopsis.
BMC plant biology · 2026 Jul 17 · DOI: 10.1186/s12870-026-09534-2
Targeting Sirtuin Signaling in Parkinson's Disease and Neurodegeneration: Molecular Insights and Translational Potential.
Molecular neurobiology · 2026 Jul 17 · DOI: 10.1007/s12035-026-06062-w
Multi-module immobilization of Gluconobacter frateurii alcohol dehydrogenase and Lactobacillus brevis NADH oxidase with tethered nicotinamide adenine dinucleotide for D-allulose biosynthesis.
International journal of biological macromolecules · 2026 Jul 17 · DOI: 10.1016/j.ijbiomac.2026.153590
SLC25A51 and mitochondrial NAD⁺ transport in acute myeloid leukemia: mechanisms, therapeutic potential, and translational perspectives.
Human cell · 2026 Jul 19 · DOI: 10.1007/s13577-026-01428-7
NOX4 promotes wear particle-stimulated inflammation and osteolysis by ROS-dependent NLRP3 inflammasome activation.
Pakistan journal of pharmaceutical sciences · 2026 Oct · DOI: 10.36721/PJPS.2026.39.10.287.1
Decoding lactate signals in Alzheimer's disease: redox control, receptor pharmacology, lactylation chemistry, and neuroglial vulnerability.
Biochemical pharmacology · 2026 Jul 20 · DOI: 10.1016/j.bcp.2026.118275
Numerical simulation of mitochondrial systems for ATP generation and membrane transport.
Scientific reports · 2026 Jul 20 · DOI: 10.1038/s41598-026-61463-0
Metabolite-Specific Reproducibility of Cerebral (31)P-MRS at 3 T: Implications for Clinical Research.
NMR in biomedicine · 2026 Sep · DOI: 10.1002/nbm.70362
A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026 Jul · DOI: 10.1002/alz.71605
Heat stress-induced degradation of glutamine synthetase rebalances central carbon-nitrogen metabolism and promotes thermotolerance in Ganoderma lucidum.
Applied and environmental microbiology · 2026 Jul 21 · DOI: 10.1128/aem.00602-26
Dual compartment lipid carriers hijack exocytosis to empower natural killer cells against solid tumours.
Nature communications · 2026 Jul 21 · DOI: 10.1038/s41467-026-75852-6
The role of redox state in regulating plant secondary metabolism under stress.
Functional plant biology : FPB · 2026 Jul 24 · DOI: 10.1071/FP25221
SIRT Family: Biological Functions and Therapeutic Targets.
MedComm · 2026 Aug · DOI: 10.1002/mco2.70866
Conformational diversity and interaction signatures of NADH across protein families.
Journal of biomolecular structure & dynamics · 2026 Jul 23 · DOI: 10.1080/07391102.2026.2704108
Targeting the NAD(+) salvage pathway: Identification of bifunctional NAMPT inhibitors and SIRT1 activators through pharmacophore-based virtual screening.
Bioorganic & medicinal chemistry · 2026 Jul 19 · DOI: 10.1016/j.bmc.2026.118754
Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism.
Acta neuropathologica · 2026 Jul 23 · DOI: 10.1007/s00401-026-03048-9