{
  "data": {
    "id": "retatrutide",
    "canonicalName": "Retatrutide",
    "aliases": [
      "LY3437943"
    ],
    "exactForm": "pending",
    "route": "pending",
    "dosageForm": "pending",
    "intendedUse": "human use (unspecified)",
    "productStatus": "Not verified",
    "compoundingStatus": "Not verified",
    "evidenceTier": "34 registered clinical studies",
    "answer": "Retatrutide is listed in the CompoundedGuide registry with no verified FDA-approved product. Retatrutide is not on FDA's 503B Bulks List for outsourcing facilities (list checked 2026-07-25). 34 registered ClinicalTrials.gov studies cite Retatrutide (19 completed, 11 active not recruiting, 3 recruiting, 1 available); registration is not evidence of approval, efficacy, or safety. Identity and regulatory status are pending source collection and editorial review. This is not medical advice.",
    "uncertainty": [
      "Exact form, route, and dosage form are not yet resolved.",
      "No FDA-approved product has been verified for this substance.",
      "Trial counts are read from a captured ClinicalTrials.gov response citing 34 specific study records, not from an open search.",
      "503B Bulks List membership was read from the list page captured 2026-07-25; being off that list is not itself a statement that compounding is lawful or unlawful.",
      "Compounding status, shortage status, and safety profile are not yet verified.",
      "This is not a medical, legal, or professional endorsement."
    ],
    "lane": "pending",
    "commercialPolicy": "none",
    "reviewedAt": "2026-07-25",
    "sources": [
      {
        "id": "fda_503b_bulks",
        "title": "503B Bulks List and Interim Categories",
        "authorityTier": "P0",
        "url": "https://www.fda.gov/drugs/human-drug-compounding/503b-bulk-drug-substances-list",
        "retrievedAt": "2026-07-25T04:39:34.819Z"
      },
      {
        "id": "clinicaltrials_gov_api",
        "title": "ClinicalTrials.gov API v2",
        "authorityTier": "P0",
        "url": "https://clinicaltrials.gov/api/v2/studies?filter.ids=NCT03841630,NCT04143802,NCT04823208,NCT04867785,NCT04881760,NCT05445232,NCT05548231,NCT05611957,NCT05882045,NCT05916560,NCT05929066,NCT05929079,NCT05931367,NCT05936151,NCT05959096,NCT06003465,NCT06039826,NCT06260722,NCT06297603,NCT06313528,NCT06354660,NCT06383390,NCT06662383,NCT06808802,NCT06859268,NCT06982846,NCT06982859,NCT07035093,NCT07165028,NCT07226947,NCT07232719,NCT07357415,NCT07467447,NCT07629401&pageSize=50&countTotal=true",
        "retrievedAt": "2026-07-25T01:36:49.295Z"
      }
    ],
    "trials": [
      {
        "nctId": "NCT07357415",
        "title": "A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE3",
        "startYear": "2026"
      },
      {
        "nctId": "NCT07467447",
        "title": "Effect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are Overweight",
        "status": "RECRUITING",
        "phase": "PHASE2",
        "startYear": "2026"
      },
      {
        "nctId": "NCT06808802",
        "title": "To Investigate the Effect of Retatrutide (LY3437943) on Metoprolol Pharmacokinetics in Healthy Participants",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2025"
      },
      {
        "nctId": "NCT06982846",
        "title": "A Study to Investigate the Response of Participants With Type 2 Diabetes Mellitus on Once-Weekly Retatrutide to Hypoglycemia",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2025"
      },
      {
        "nctId": "NCT06982859",
        "title": "A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE1",
        "startYear": "2025"
      },
      {
        "nctId": "NCT07226947",
        "title": "Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment",
        "status": "RECRUITING",
        "phase": "NA",
        "startYear": "2025"
      },
      {
        "nctId": "NCT06859268",
        "title": "A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE3",
        "startYear": "2025"
      },
      {
        "nctId": "NCT07165028",
        "title": "A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)",
        "status": "RECRUITING",
        "phase": "PHASE3",
        "startYear": "2025"
      },
      {
        "nctId": "NCT07232719",
        "title": "A Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE3",
        "startYear": "2025"
      },
      {
        "nctId": "NCT07035093",
        "title": "A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE3",
        "startYear": "2025"
      },
      {
        "nctId": "NCT06297603",
        "title": "Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE3",
        "startYear": "2024"
      },
      {
        "nctId": "NCT06260722",
        "title": "Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE3",
        "startYear": "2024"
      },
      {
        "nctId": "NCT06313528",
        "title": "A Study to Measure Calorie Consumption and Usage in Participants With Obesity Using LY3437943",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2024"
      },
      {
        "nctId": "NCT06662383",
        "title": "A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE3",
        "startYear": "2024"
      },
      {
        "nctId": "NCT06383390",
        "title": "The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE3",
        "startYear": "2024"
      },
      {
        "nctId": "NCT06354660",
        "title": "Effect of Retatrutide Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1)",
        "status": "COMPLETED",
        "phase": "PHASE3",
        "startYear": "2024"
      },
      {
        "nctId": "NCT05959096",
        "title": "A Study of LY3437943 in Healthy Participants With a High Body Mass Index",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2023"
      },
      {
        "nctId": "NCT05916560",
        "title": "A Study of LY3437943 in Participants With Impaired and Normal Liver Function",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2023"
      },
      {
        "nctId": "NCT05882045",
        "title": "A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE3",
        "startYear": "2023"
      },
      {
        "nctId": "NCT06039826",
        "title": "A Study of LY3437943 in Postmenopausal Female Participants Who Are Overweight or Obese",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2023"
      },
      {
        "nctId": "NCT05929066",
        "title": "A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight",
        "status": "COMPLETED",
        "phase": "PHASE3",
        "startYear": "2023"
      },
      {
        "nctId": "NCT05929079",
        "title": "A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE3",
        "startYear": "2023"
      },
      {
        "nctId": "NCT05936151",
        "title": "A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "startYear": "2023"
      },
      {
        "nctId": "NCT06003465",
        "title": "A Research Study Looking at Similarity Between LY3437943 Versions for Different Injection Devices",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2023"
      },
      {
        "nctId": "NCT05931367",
        "title": "A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee",
        "status": "COMPLETED",
        "phase": "PHASE3",
        "startYear": "2023"
      },
      {
        "nctId": "NCT05445232",
        "title": "A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese Participants",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2022"
      },
      {
        "nctId": "NCT05548231",
        "title": "A Study of LY3437943 in Chinese Participants With Obesity Or Overweight",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2022"
      },
      {
        "nctId": "NCT05611957",
        "title": "A Study of LY3437943 in Healthy Participants and Participants With Impaired Renal Function",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2022"
      },
      {
        "nctId": "NCT04867785",
        "title": "A Study of LY3437943 in Participants With Type 2 Diabetes",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "startYear": "2021"
      },
      {
        "nctId": "NCT04823208",
        "title": "A Study of LY3437943 in Japanese Participants With Type 2 Diabetes Mellitus (T2DM)",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2021"
      },
      {
        "nctId": "NCT04881760",
        "title": "A Study of LY3437943 in Participants Who Have Obesity or Are Overweight",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "startYear": "2021"
      },
      {
        "nctId": "NCT03841630",
        "title": "A Safety Study of LY3437943 Given as a Single Injection in Healthy Participants",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2019"
      },
      {
        "nctId": "NCT04143802",
        "title": "A Study of LY3437943 in Participants With Type 2 Diabetes Mellitus (T2DM)",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2019"
      },
      {
        "nctId": "NCT07629401",
        "title": "Provide Pre-approval Expanded Access of LY3437943",
        "status": "AVAILABLE",
        "phase": "",
        "startYear": ""
      }
    ],
    "pendingResources": {
      "identity": [
        "FDA/NCATS GSRS or equivalent canonical identity source"
      ],
      "product_status": [
        "Drugs@FDA, Purple Book, Orange Book, DailyMed, or applicable primary FDA record"
      ],
      "compounding_status": [
        "FDA 503A/503B pages, Federal Register, docket, or applicable final/interim policy"
      ],
      "safety": [
        "FDA safety communication, warning, recall, FAERS signal context, or explicit absence statement"
      ],
      "evidence": [
        "ClinicalTrials.gov and PubMed/primary publication search"
      ],
      "state_or_facility": [
        "State board or FDA facility record when relevant"
      ]
    }
  }
}