{
  "data": {
    "id": "nad-plus",
    "canonicalName": "NAD+",
    "aliases": [
      "Nicotinamide adenine dinucleotide"
    ],
    "exactForm": "pending",
    "route": "pending",
    "dosageForm": "pending",
    "intendedUse": "human use (unspecified)",
    "productStatus": "Not verified",
    "compoundingStatus": "Not verified",
    "evidenceTier": "50 registered clinical studies",
    "answer": "NAD+ is listed in the CompoundedGuide registry with no verified FDA-approved product. NAD+ is not on FDA's 503B Bulks List for outsourcing facilities (list checked 2026-07-25). 50 registered ClinicalTrials.gov studies cite NAD+ (17 completed, 13 unknown, 11 recruiting, 4 terminated, 3 active not recruiting, 1 not yet recruiting, 1 withdrawn); registration is not evidence of approval, efficacy, or safety. Identity and regulatory status are pending source collection and editorial review. This is not medical advice.",
    "uncertainty": [
      "Exact form, route, and dosage form are not yet resolved.",
      "No FDA-approved product has been verified for this substance.",
      "Trial counts are read from a captured ClinicalTrials.gov response citing 50 specific study records, not from an open search.",
      "503B Bulks List membership was read from the list page captured 2026-07-25; being off that list is not itself a statement that compounding is lawful or unlawful.",
      "Compounding status, shortage status, and safety profile are not yet verified.",
      "This is not a medical, legal, or professional endorsement."
    ],
    "lane": "pending",
    "commercialPolicy": "none",
    "reviewedAt": "2026-07-25",
    "sources": [
      {
        "id": "fda_503b_bulks",
        "title": "503B Bulks List and Interim Categories",
        "authorityTier": "P0",
        "url": "https://www.fda.gov/drugs/human-drug-compounding/503b-bulk-drug-substances-list",
        "retrievedAt": "2026-07-25T04:39:34.001Z"
      },
      {
        "id": "clinicaltrials_gov_api",
        "title": "ClinicalTrials.gov API v2",
        "authorityTier": "P0",
        "url": "https://clinicaltrials.gov/api/v2/studies?filter.ids=NCT00386126,NCT00969527,NCT01575899,NCT01949545,NCT01980589,NCT02150616,NCT02157974,NCT02245620,NCT02303821,NCT02463110,NCT02523040,NCT02536846,NCT02601157,NCT03562468,NCT04082559,NCT04192136,NCT04228640,NCT04239599,NCT04257409,NCT04287543,NCT04344769,NCT04550507,NCT04562831,NCT04661995,NCT04870125,NCT04934189,NCT04964492,NCT05096962,NCT05169554,NCT05393115,NCT05405309,NCT05405868,NCT05468684,NCT05485610,NCT05497609,NCT05571748,NCT05631717,NCT05759468,NCT06425042,NCT06488339,NCT06558253,NCT06815237,NCT06841809,NCT06847126,NCT06889142,NCT07150455,NCT07229638,NCT07255378,NCT07428889,NCT07659834&pageSize=50&countTotal=true",
        "retrievedAt": "2026-07-25T01:36:47.109Z"
      }
    ],
    "trials": [
      {
        "nctId": "NCT07428889",
        "title": "Nicotinamide Adenine Dinucleotide Responses to a Nutritional Supplement",
        "status": "RECRUITING",
        "phase": "NA",
        "startYear": "2026"
      },
      {
        "nctId": "NCT07659834",
        "title": "Food Supplement for Longevity",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "NA",
        "startYear": "2026"
      },
      {
        "nctId": "NCT07229638",
        "title": "A IB/II Phase Clinical Study on the Safety, Tolerability, and Efficacy of SHR-9839(sc) in Combination Anti-tumor Therapy in Patients With Solid Tumors",
        "status": "RECRUITING",
        "phase": "PHASE1/PHASE2",
        "startYear": "2026"
      },
      {
        "nctId": "NCT06815237",
        "title": "Effects of Ketone Supplement and Alcohol on Brain Metabolism",
        "status": "RECRUITING",
        "phase": "PHASE2/PHASE3",
        "startYear": "2025"
      },
      {
        "nctId": "NCT06841809",
        "title": "Analysis of Radiographic Indices in Carpal Tunnel Syndrome",
        "status": "COMPLETED",
        "phase": "",
        "startYear": "2025"
      },
      {
        "nctId": "NCT06889142",
        "title": "Impact of NMN Supplementation on CD4+ T Cell Recovery in HIV Patients With Immunological Failure",
        "status": "NOT_YET_RECRUITING",
        "phase": "NA",
        "startYear": "2025"
      },
      {
        "nctId": "NCT07255378",
        "title": "Use of Vassopresin in Septic Shock Prospective Multicenter Observational Study With Medication",
        "status": "RECRUITING",
        "phase": "",
        "startYear": "2025"
      },
      {
        "nctId": "NCT06847126",
        "title": "Empirical Intravenous Beta-Lactam Plus Metronidazole Vs Oral Cefixime Plus Metronidazole for the Treatment of Liver Abscess",
        "status": "RECRUITING",
        "phase": "PHASE3",
        "startYear": "2025"
      },
      {
        "nctId": "NCT07150455",
        "title": "Evaluation of Myocardial Function by Global Longitudinal Strain (GLS) Measurement in 2D Echocardiography of Patients With Fibromyalgia",
        "status": "COMPLETED",
        "phase": "",
        "startYear": "2025"
      },
      {
        "nctId": "NCT06425042",
        "title": "Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity",
        "status": "RECRUITING",
        "phase": "NA",
        "startYear": "2024"
      },
      {
        "nctId": "NCT06558253",
        "title": "The Safety and Efficacy of Coenzyme I for Injection in Promoting Hematopoietic Recovery of Patients After sUCBT",
        "status": "RECRUITING",
        "phase": "PHASE1",
        "startYear": "2024"
      },
      {
        "nctId": "NCT06488339",
        "title": "Food Replacement on Weight Control in Overweight Volunteers",
        "status": "UNKNOWN",
        "phase": "NA",
        "startYear": "2024"
      },
      {
        "nctId": "NCT05405868",
        "title": "Nicotinamide in Glaucoma (NAMinG): A Randomised, Placebo-controlled, Multi-centre, Phase III Trial",
        "status": "RECRUITING",
        "phase": "PHASE3",
        "startYear": "2024"
      },
      {
        "nctId": "NCT05571748",
        "title": "Oxidative Stress, Carbohydrate Metabolism Disorders and G6PD Deficiency",
        "status": "UNKNOWN",
        "phase": "NA",
        "startYear": "2023"
      },
      {
        "nctId": "NCT05759468",
        "title": "NAD Augmentation in Diabetes Kidney Disease",
        "status": "RECRUITING",
        "phase": "PHASE2",
        "startYear": "2023"
      },
      {
        "nctId": "NCT04870125",
        "title": "Safety Study of Inhaled Carbon Monoxide to Treat Pneumonia and Sepsis-Induced Acute Respiratory Distress Syndrome (ARDS)",
        "status": "TERMINATED",
        "phase": "PHASE1",
        "startYear": "2023"
      },
      {
        "nctId": "NCT04661995",
        "title": "Notched Noise Therapy for Suppression of Tinnitus",
        "status": "COMPLETED",
        "phase": "NA",
        "startYear": "2023"
      },
      {
        "nctId": "NCT05468684",
        "title": "PROCO Neck: The Course and Neuroplasticity in Neck Pain-Associated Disorders and Whiplash-Associated Disorders",
        "status": "UNKNOWN",
        "phase": "",
        "startYear": "2022"
      },
      {
        "nctId": "NCT05631717",
        "title": "The Study of Comparing the Efficacy and Safety of Human Umbilical Cord MSCs and Low-dose IL-2 in the Treatment of LN",
        "status": "UNKNOWN",
        "phase": "PHASE3",
        "startYear": "2022"
      },
      {
        "nctId": "NCT05405309",
        "title": "RP-3500 and Olaparib in DNA Damage Repair Pathway Deficient Relapsed/Refractory Chronic Lymphocytic Leukemia",
        "status": "TERMINATED",
        "phase": "PHASE1/PHASE2",
        "startYear": "2022"
      },
      {
        "nctId": "NCT05485610",
        "title": "Effect of NMN (Nicotinamide Mononucleotide) on Diminished Ovarian Reserve (Including Premature Ovarian Insufficiency)",
        "status": "UNKNOWN",
        "phase": "NA",
        "startYear": "2022"
      },
      {
        "nctId": "NCT05096962",
        "title": "COVID-19: SARS-CoV-2-CZ-PREVAL-II Study",
        "status": "COMPLETED",
        "phase": "",
        "startYear": "2021"
      },
      {
        "nctId": "NCT04287543",
        "title": "Melatonin on Clock Genes in Parkinson's Disease",
        "status": "WITHDRAWN",
        "phase": "PHASE2/PHASE3",
        "startYear": "2021"
      },
      {
        "nctId": "NCT05393115",
        "title": "Respiratory Muscle Fatigue at Different Breathing Modes",
        "status": "UNKNOWN",
        "phase": "NA",
        "startYear": "2021"
      },
      {
        "nctId": "NCT04934189",
        "title": "Empowerment Self-Defense Training for the Prevention of Victimization of Transgender Women",
        "status": "COMPLETED",
        "phase": "NA",
        "startYear": "2021"
      },
      {
        "nctId": "NCT05169554",
        "title": "Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy",
        "status": "UNKNOWN",
        "phase": "PHASE2",
        "startYear": "2021"
      },
      {
        "nctId": "NCT04228640",
        "title": "Evaluate the Efficacy and Safety of Uthever NMN(Nicotinamide Mononucleotide, a Form of Vitamin B3)",
        "status": "COMPLETED",
        "phase": "NA",
        "startYear": "2020"
      },
      {
        "nctId": "NCT04550507",
        "title": "Mind-Body Interventions to Mitigate Effects of Media Use on Sleep in Early Adolescents",
        "status": "UNKNOWN",
        "phase": "NA",
        "startYear": "2020"
      },
      {
        "nctId": "NCT04964492",
        "title": "Assessment of the Hemodynamic Effect of Hydroxocabalamin in Refractory Vasodilatory Shock",
        "status": "COMPLETED",
        "phase": "",
        "startYear": "2020"
      },
      {
        "nctId": "NCT04192136",
        "title": "NAD+ and Exercise in FA",
        "status": "COMPLETED",
        "phase": "NA",
        "startYear": "2020"
      },
      {
        "nctId": "NCT04562831",
        "title": "The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS.",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "NA",
        "startYear": "2020"
      },
      {
        "nctId": "NCT04082559",
        "title": "Biomarker-based Multidisciplinary Team (Bio-MDT) Approach to Personalized Microbial-targeted Treatment of Pouchitis and Crohn's Disease",
        "status": "UNKNOWN",
        "phase": "NA",
        "startYear": "2019"
      },
      {
        "nctId": "NCT04257409",
        "title": "Musculoskeletal Changes After Physiotherapeutic Intervention in Podiatric Subjects",
        "status": "UNKNOWN",
        "phase": "NA",
        "startYear": "2019"
      },
      {
        "nctId": "NCT04344769",
        "title": "Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)",
        "status": "RECRUITING",
        "phase": "",
        "startYear": "2019"
      },
      {
        "nctId": "NCT03562468",
        "title": "A Study by ChromaDex to Assess the Effects of TRU NIAGEN on Cognitive Function, Mood and Sleep in Older Adults",
        "status": "COMPLETED",
        "phase": "NA",
        "startYear": "2018"
      },
      {
        "nctId": "NCT02536846",
        "title": "The Effects of Antipsychotic Drugs on Brain Metabolism in Healthy Individuals",
        "status": "COMPLETED",
        "phase": "PHASE4",
        "startYear": "2017"
      },
      {
        "nctId": "NCT02601157",
        "title": "Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - Coronary Intervention With Next Generation Drug-Eluting Stent Platforms and Abbreviated Dual Antiplatelet Therapy (HOST-IDEA) Trial",
        "status": "COMPLETED",
        "phase": "PHASE4",
        "startYear": "2016"
      },
      {
        "nctId": "NCT02523040",
        "title": "Lenalidomide for Adult Histiocyte Disorders",
        "status": "ACTIVE_NOT_RECRUITING",
        "phase": "PHASE2",
        "startYear": "2015"
      },
      {
        "nctId": "NCT02463110",
        "title": "Acute Myocardial Necrosis and Depression: Antiplatelet Effect of Reuptake Inhibition of Serotonin",
        "status": "TERMINATED",
        "phase": "PHASE4",
        "startYear": "2015"
      },
      {
        "nctId": "NCT02245620",
        "title": "A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendavia™) on Skeletal Muscle Function in Elderly",
        "status": "COMPLETED",
        "phase": "PHASE2",
        "startYear": "2015"
      },
      {
        "nctId": "NCT02303821",
        "title": "Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2015"
      },
      {
        "nctId": "NCT02150616",
        "title": "Patients With Pulmonary Hypertension or Interstitial Lung Disease at Altitude - Effect of Oxygen on Breathing and Sleep",
        "status": "UNKNOWN",
        "phase": "PHASE4",
        "startYear": "2014"
      },
      {
        "nctId": "NCT02157974",
        "title": "Liver and Fat Regulation in Overweight Adolescent Girls",
        "status": "COMPLETED",
        "phase": "PHASE2/PHASE3",
        "startYear": "2014"
      },
      {
        "nctId": "NCT01949545",
        "title": "Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Advanced Malignancies and Hepatic Impairment",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2013"
      },
      {
        "nctId": "NCT01980589",
        "title": "A Multicenter, Open-label, Phase 1b Study of Carfilzomib, Cyclophosphamide and Dexamethasone in Newly Diagnosed Multiple Myeloma Subjects",
        "status": "COMPLETED",
        "phase": "PHASE1",
        "startYear": "2013"
      },
      {
        "nctId": "NCT04239599",
        "title": "Trial of Hypofractionated IMRT Boost Versus Conventional IMRT Boost for Localized High Risk Prostate Cancer",
        "status": "UNKNOWN",
        "phase": "NA",
        "startYear": "2011"
      },
      {
        "nctId": "NCT00969527",
        "title": "Efficacy of Oncoxin Plus Viusid in the Treatment of Rheumatoid Arthritis",
        "status": "COMPLETED",
        "phase": "PHASE3",
        "startYear": "2009"
      },
      {
        "nctId": "NCT01575899",
        "title": "Efficacy of Seven-day Combined Rabeprazole Plus Levofloxacin Plus Augmentin for Eradication of Helicobacter Pylori",
        "status": "TERMINATED",
        "phase": "PHASE4",
        "startYear": "2007"
      },
      {
        "nctId": "NCT05497609",
        "title": "The Muscle in Children With Cerebral Palsy - Longitudinal Exploration of Microscopic Muscle Structure.",
        "status": "RECRUITING",
        "phase": "",
        "startYear": "2006"
      },
      {
        "nctId": "NCT00386126",
        "title": "Iron Supplementation in Heart Failure Patients With Anemia: The IRON-HF Study",
        "status": "UNKNOWN",
        "phase": "PHASE2/PHASE3",
        "startYear": "2006"
      }
    ],
    "pendingResources": {
      "identity": [
        "FDA/NCATS GSRS or equivalent canonical identity source"
      ],
      "product_status": [
        "Drugs@FDA, Purple Book, Orange Book, DailyMed, or applicable primary FDA record"
      ],
      "compounding_status": [
        "FDA 503A/503B pages, Federal Register, docket, or applicable final/interim policy"
      ],
      "safety": [
        "FDA safety communication, warning, recall, FAERS signal context, or explicit absence statement"
      ],
      "evidence": [
        "ClinicalTrials.gov and PubMed/primary publication search"
      ],
      "state_or_facility": [
        "State board or FDA facility record when relevant"
      ]
    }
  }
}